LISA summaries:

 
 
 

Changes in practice of less-invasive surfactant administration (LISA) in United Kingdom neonatal units (2024) 

 

Sandeep Shetty, Donna Tolentino, Cheryl Lau, Donovan Duffy, Anne Greenough 

 

This study tracks the significant rise in LISA across every UK neonatal unit, with usage rising from 19% in 2018 to 70% in 2024. Despite this progress, challenges like training gaps and logistical barriers still limit wider adoption.

 

Read how these findings spotlight a shift toward less-invasive neonatal respiratory care, underscoring the need for standardised training and protocols to fully realise LISA’s benefits for preterm infants. 

 
 
 

Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome (Review) (2021) 

 

Abdel-Latif ME, Davis PG, Wheeler KI, De Paoli AG, Dargaville PA 

 

This Cochrane review assessed the effectiveness of surfactant administration via LISA compared with traditional endotracheal intubation for preterm infants with RDS. Drawing on data from 16 randomised trials with over 2,100 preterm infants, the review found that LISA significantly reduced the risk of death or BPD, need for intubation, and severe complications compared with surfactant administration via endotracheal tube. 

Read more to see how these findings support LISA as a more effective, less-invasive approach for surfactant delivery in neonatal respiratory care, highlighting its positioning as a new standard of care. 

 
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Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome — The OPTIMIST-A Randomized Clinical Trial (2021) 

 

Dargaville PA, Kamlin OF, Orsini F, Wang X, De Paoli AG, et al.

 

OPTIMIST-A was a pivotal trial that provided important findings on the use of LISA in 485 preterm infants with RDS who were supported on continuous positive airway pressure (CPAP) and had an FiO2 ≥0.3. While LISA did not significantly affect the combined rates of death or BPD, it notably reduced BPD among survivors and decreased the need for intubation within the first 72 hours of life. 

Read more about how this study positioned LISA as a technique for helping to mitigate respiratory complications in neonatal care. 

 
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